ATF3 is a negative regulator of inflammation in human fetal membranes

R Lim; G Barker; S Liong; C Nguyen-Ngo; S Tong; T Kaitu'u-Lino; M Lappas

Journal article

ATF3 is a negative regulator of inflammation in human fetal membranes

R Lim, G Barker, S Liong, C Nguyen-Ngo, S Tong, T Kaitu'u-Lino, M Lappas

Placenta | W B SAUNDERS CO LTD | Published : 2016

DOI: 10.1016/j.placenta.2016.09.006

Abstract

Introduction Infection and inflammation stimulate pro-inflammatory cytokines, prostaglandins and matrix metalloproteinase (MMP)-9, which play a central role in myometrial contractions and rupture of fetal membranes. In human and mouse immune cells, activating transcription factor 3 (ATF3) is a negative regulator of inflammation. No studies have examined the role of ATF3 in human labour. Methods Primary amnion cells were used to determine the effect of interleukin (IL)-1β and the bacterial product fibroblast-stimulating lipopeptide (fsl-1) on ATF3 expression, and the effect of ATF3 siRNA on pro-labour mediators. ATF3 expression was assessed in fetal membranes from non-labouring and labouring ..

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University of Melbourne Researchers

Stephen Tong Author

Tu'uhevaha Kaitu'u-Lino Author

Martha Lappas Author

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Grants

Awarded by Norman Beischer Medical Research Foundation

Funding Acknowledgements

ML, KT and ST are supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC #1047025, #1050765, #1062418). Funding for this study was provided by the NHMRC (grant no. 1058786), Norman Beischer Medical Research Foundation and the Mercy Research Foundation.